Volume 11 Issue 2
A prospective study evaluating the effectiveness of three different intranasal dexmedetomidine doses for pediatric premedication
1Ali Raza, 2Ali Mohib, 3Kashif Lodhi, 4Hammad Ali, 5Dr. Syed Imtiaz Ali Zaidi, 6Dr. Abaid ur Rehman
1PIMS
2PIMS
3Department of Agricultural, Food and Environmental Sciences. Università Politécnica delle Marche Via Brecce Bianche 10, 60131 Ancona (AN) Italy
4PIMS
5Assistant Professor, Department of Anaesthesiology & Intensive Care, Avicenna Medical College & Hospital, Lahore, Pakistan
6Associate Professor, Anesthesia, Rashid Latif Medical College/ Hameed Latif hospital Lahore
ABSTRACT
OBJECTIVE: Preoperative anxiety may be upsetting for children having surgery, and treating it well can improve the anesthetic results. This study aim is to assess the effectiveness of three different intranasal dexmedetomidine doses for pediatric premedication.
METHODS: The medicine was given 45 minutes before to the onset of anesthesia after randomly allocating 60 kids to one of three groups. Anxiety levels, induction compliance, and hemodynamic responses were all measured using the modified Yale Preoperative Anxiety Scale at various time points.
RESULTS: The results demonstrated that anxiety might be decreased from baseline levels with lower dosages of 0.5 and 1 µg/kg, but were insufficient to provide anxiolysis during the two most stressful times of childbirth: when the parents are separated from the child and when the child is moved into the operating room. It was discovered that the ideal dosage of 1.5 µg/kg significantly reduced preoperative anxiety without causing any negative side effects, but it did not optimize induction since it was predominantly anxiolytic.
CONCLUSIONS: Based on these results, the research advises using intranasal dexmedetomidine at a dosage of 1.5g/kg for lowering preoperative anxiety in children, while greater doses could be necessary for the best results during induction. This research emphasizes how crucial it is to treat preoperative anxiety in young patients and the possible advantages of employing intranasal dexmedetomidine as a premedication.
KEYWORDS: anxiety, premedication, intranasal dexmedetomidine, pediatrics