Volume 11 Issue 1
Determining the stages of kaposi sarcoma through histopathological analysis: identifying the most effective findings
1Dr. Shahid Hasnain Siddiqui, 2Kashif Lodhi, 3Dr Ayesha Imtiaz Malik, 4Dr. Hafiz Muhammad Jahan Zaib, 5Khurram Shahzad, 6Kashif Lodhi
1Assistant Professor Histopathology, Jinnah Medical College Peshawar, drshahidhasnain@hotmail.com
2Department of Agricultural, Food and Environmental Sciences. Università Politécnica delle Marche Via Brecce Bianche 10, 60131 Ancona (AN) Italy
3Associate Professor Histopathology, M. Islam Medical and Dental college Gujranwala ,
4Ophthalmology, Federal Government Polyclinic, Postgraduate Medical Institute, Islamabad, Pakistan,
5HIESS, Hamdard University, Karachi
6Department of Agricultural, Food and Environmental Sciences. Università Politécnica delle Marche Via Brecce Bianche 10, 60131 Ancona (AN) Italy
Abstract
Objective: Kaposi sarcoma (KS) is a locally malignant angio-proliferative tumor that manifests itself in a variety of histological ways at different stages. Depending on the stage, frequency, and findings they are associated with, histopathological results might have diagnostic relevance. The goal of the research was to establish a finding or set of results, that is significant at distinct phases of KS and can be used to accurately pinpoint that stage.
Methods: The diagnosis of KS patients was examined retrospectively. Investigations were done on the connections between morphological factors and illness phases. The method of multivariate regression and the Chi-Square test were employed in the comparison analysis. The acceptable statistical significance threshold was a p-value less than 0.05.
Results: In this study, different phases of a given condition were analyzed, and it was discovered that there were statistically significant variations in the presence of specific parameters at various stages. With a 25.7 times higher odds ratio, the research showed that the presence of hemosiderin was substantially more common in the plaque stage compared to the patch stage. Similar to this, the odds ratio for the occurrence of mitosis was 3.7 times greater in the nodule stage compared to the plaque stage.
Conclusions: The most reliable and definitive histopathological outcomes for the relevant stage should be used to determine the KS diagnosis.
Keywords: histopathology, kaposi sarcoma, findings