Volume 11 Issue 5
EFFECTS OF ESCITALOPRAM ALONE AND IN COMBINATION WITH ASCORBIC ACID, VITAMIN-E, AND LEVOSULPRIDE ON THE LEVELS OF SUPEROXIDE DISMUTASE (SOD) AND GLUTATHIONE PEROXIDASE AMONG DEPRESSION PATIENTS
1Dr. Muhammad Anwar Bangulzai, 2Prof. Dr. Kausar Aamir, 3Dr Muhammad Abid, 4Dr Waheeda Baloch, 5Prof Dr Azhar Memon, 6Dr Shuja Anwer Kazi
1Assistant Professor, Jhalawan Medical College Khuzdar
2Professor, Department of Pharmacology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Center, Karachi, Sindh, Pakistan
3Associate Professor, Department of Pharmacology, Bolan Medical College, Quetta, Pakistan
4Consultant physician، Shaheed mohtarma Benazir Bhutto General (S۔M۔S۔B۔B۔G) hospital ،Quetta
5Professor, Department of Medicine, Suleman Roshan Medical College Tando Adam, Sindh, Pakistan
6Assistant Professor, King Faisal University Al-Ahsa Kingdom of Saudi Arabia
Correspondence: Dr. Muhammad Anwar Bangulzai, Assistant Professor, Jhalawan medical College Khuzdar
Abstract
Introduction This study aims to make progress in discovering objective and clinically relevant biomarkers, so presenting the potential of improved diagnostic precision and customized therapy approaches for those suffering from depression.
Methodology Participants for the study, aged 20 to 70, were chosen at random from the Baluchistan Institute of Psychiatry and Behavioural Sciences (BIPS) in Quetta. Experienced psychiatrists who were familiar with the DSM-5 categorization system performed in-depth patient interviews and made diagnoses. Symptoms closely related with Major Depressive Disorder (MDD) were rigorously assessed as part of the clinical evaluation, depending on both patient medical histories and extensive physical tests.
Results The study looked at the impact of various therapies on Superoxide Dismutase (SOD) levels in four different patient groups. The analysis of variance (ANOVA) demonstrated that antidepressant therapies had a significant influence on SOD levels (p=0.00001). Notably, Group 4 (Escitalopram+Levosulpride) had significantly higher SOD levels (11.15±0.57 IU) than Group 1 (Control) (9.55±0.65 IU). This increase was statistically significant (p<0.05), indicating that the Escitalopram+Levosulpride intervention had a meaningful effect on increasing SOD activity. In comparison to the Control group, Group 2 (Escitalopram + Vitamin C) and Group 3 (Escitalopram
+ Vitamin E) did not show significant changes in SOD levels (9.89±0.58 IU and 10.69±0.59 IU, respectively).
Conclusion The combination of Escitalopram and Levosulpride had encouraging effects on both SOD and GP levels, highlighting the possibility of personalized therapy methods in modifying antioxidant enzyme activity.
Keywords Depression, Glutathione Peroxidase, Superoxide Dismutase