Volume 9 Issue 2
An Update on 2,5-Diketopiperazines from Marine Organisms
Ri-Ming Huang, Xiang-Xi Yi, Yuying Zhou, Xiangdong Su, Yan Peng and Cheng-Hai Gao
1Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
2Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
3School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
4Department of Cell Biology, Jinan University, Guangzhou 510632, China
5Life Science & Technology School, Lingnan Normal University, Zhanjiang 52048, China
6Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China
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Author to whom correspondence should be addressed.
Abstract
2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms. Because of the increasing numbers and biological importance of these compounds, this review covers 90 marine originated 2,5-DKPs that were reported from 2009 to the first half-year of 2014. The review will focus on the structure characterizations, biological properties and proposed biosynthetic processes of these compounds.
Keywords:2,5-diketopiperazine; marine organism; biosynthetic processes; biological activity