Volume 11 Issue 8
Curative and neurological factor variations in patients with neuropathy, polyneuropathy, and post-traumatic non-gunshot injuries: an integrated clinical assessment
1Sara Promise, 2Dr. Muhammad Ali, 3Ali Raza, 4Khurram Ali, 5Iqbal Lodhi, 6Mobeen Ali
Columbia University, Assistant Professor Department of Neurology, Nawabshah, PIMS, PIMS, UHS, PIMS
Abstract
Background: Peripheral neuropathy is also known as polyneuropathy which is a multifaceted neurological disorder entailing damage to nerves resulting in a range of symptoms with regard to sensory, motor, and autonomic systems. Non-penetrating trauma gunshots are another category of such disorders in which damage to nerves occurs due to trauma but no involvement of gunshots is there. Knowing the type of cure that is possible and the differences in neurological setup in such patients is crucial in the management of such patients and early intervention.
Aim: The purpose of this research is to compare the changes in the prognosis of the cure and the distinct neurological features of patients with neuropathy, polyneuropathy, and post- traumatic, non-gunshot neuropathy patients. This approach aims at establishing criteria in early recovery and at measuring the outcome of various treatment approaches.
Method: Patients of a tertiary care centre along with multiple affiliated hospitals were included in this study from January 2020 to December 2024 adopting a retrospective cohort study model. Participants were the adults 18- to 65-year old suffering neuropathy, polyneuropathy, or with traumatic injuries not related to gunshot. Information regarding the patients was obtained about their age, gender, injury nature, neurological status and their management. Neurological recovery and curative response were the primary endpoints while, factors affecting recovery were the secondary endpoints. The outcomes were compared with the ‘manual’ results and the factors that showed to be significant to the outcomes were determined using ANOVA and regression analysis.
Results: There were 350 patients in the study and neurological recovery and curative differentiation of potency were dissimilar between different groups of patients. The patients with acute neuropathy and upper limb trauma had better improved outcome in comparison with the patients with chronic neuropathy or combined trauma. Pharmacological and physical therapy was found to be superior with an over all success rate of 82%. The demographic characteristics that were found to affect recovery were age, the type of injury suffered and the time that elapses from the time of injury before the patient is treated.
Conclusion: This study also suggests that effective treatment methods should be developed for individual patients with emphasis on early intervention and interdisciplinary management to enhance recovery of functions. It is recommended to perform more extensive investigations, prospective studies as well as clinical trials to support these conclusions and investigate new possibilities for the treatment of neuropathic disorders.
Keywords: Neuropathy, Polyneuropathy, Post-Traumatic Injuries, Neurological Recovery, Curative Outcomes, Retrospective Cohort Study, Personalized Treatment.